Author:
Nitzsche K.,Fitze G.,Rüdiger M.,Wimberger P.,Birdir C.
Abstract
AbstractThe aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82.9%) with karyotyping and 16 cases (39%) with an abnormal karyotype. Outcome of 39 cases showed 6 abortions (15.4%), 15 terminations (38.5%), an intrauterine fetal death (2.5%) and 17 alive babies (43.6%), which were grouped in two: small exomphalos (n = 6, 35.3%) and big exomphalos (n = 11, 64.7%). Maximal diameter of exomphalos/abdomen circumference-ratio (EDmax/AC-ratio) with a cut-off of 0.24 showed a better predictive value of postnatal primary closure. Exomphalos is correlated with abnormal karyotype. EDmax/AC-ratio gives the best prediction for postnatal primary closure of the defect.
Funder
Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden
Publisher
Springer Science and Business Media LLC
Reference23 articles.
1. Sadler, T. W. The embryologic origin of ventral body wall defects. Semin. Pediatr. Surg. 19(3), 209–214. https://doi.org/10.1053/j.sempedsurg.2010.03.006 (2010).
2. Xing, J. et al. National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999–2001. Birth Defects Res. A 76(11), 747–756. https://doi.org/10.1002/bdra.20294 (2006).
3. Baird, P. A. & MacDonald, E. C. An epidemiologic study of congenital malformations of the anterior abdominal wall in more than half a million consecutive live births. Am. J. Hum. Genet. 33(3), 470–478 (1981).
4. Boll, J. & Luu, M. B. Abdominal wall defects. Common Surgical Diseases: An Algorithmic Approach to Problem Solving, Third Edition, 233–237. https://doi.org/10.1007/978-1-4939-1565-1_58 (2015).
5. Blazer, S., Zimmer, E. Z., Gover, A. & Bronshtein, M. Fetal Omphalocele Detected Early in Pregnancy: Associated Anomalies and Outcomes. https://doi.org/10.1148/radiol.2321030795.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献