Author:
Sunayama Tsutomu,Maeda Daichi,Matsue Yuya,Kagiyama Nobuyuki,Jujo Kentaro,Saito Kazuya,Kamiya Kentaro,Saito Hiroshi,Ogasawara Yuki,Maekawa Emi,Konishi Masaaki,Kitai Takeshi,Iwata Kentaro,Wada Hiroshi,Hiki Masaru,Dotare Taishi,Kasai Takatoshi,Nagamatsu Hirofumi,Ozawa Tetsuya,Izawa Katsuya,Yamamoto Shuhei,Aizawa Naoki,Yonezawa Ryusuke,Oka Kazuhiro,Momomura Shin-ichi,Minamino Tohru
Abstract
AbstractAlthough postural hypotension (PH) is reportedly associated with mortality in the general population, the prognostic value for heart failure is unclear. This was a post-hoc analysis of FRAGILE-HF, a prospective multicenter observational study focusing on frailty in elderly patients with heart failure. Overall, 730 patients aged ≥ 65 years who were hospitalized with heart failure were enrolled. PH was defined by evaluating seated PH, and was defined as a fall of ≥ 20 mmHg in systolic and/or ≥ 10 mmHg in diastolic blood pressure within 3 min after transition from a supine to sitting position. The study endpoints were all-cause death and heart failure readmission at 1 year. Predictive variables for the presence of PH were also evaluated. PH was observed in 160 patients (21.9%). Patients with PH were more likely than those without PH to be male with a New York Heart Association classification of III/IV. Logistic regression analysis showed that male sex, severe heart failure symptoms, and lack of administration of angiotensin-converting enzyme inhibitors were independently associated with PH. PH was not associated with 1-year mortality, but was associated with a lower incidence of readmission after discharge after adjustment for other covariates. In conclusion, PH was associated with reduced risk of heart failure readmission but not with 1-year mortality in older patients with heart failure.
Funder
Japan Society for the Promotion of Science
Japan Heart Foundation Research Grant.
Novartis Pharma Research Grants
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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