From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis-Reference-Cited by-同舟云学术

From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis

Published:2023-10-17 Issue:1 Volume:13 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Faris A.,Edder Y.,Louchachha I.,Lahcen I. Ait,Azzaoui K.,Hammouti B.,Merzouki M.,Challioui A.,Boualy B.,Karim A.,Hanbali G.,Jodeh S.

Abstract

AbstractIn this study, we report the first total hemisynthesis of trans-himachalol sesquiterpene, a stereoisomer of the natural cis-himachalol isolated from Cedrus atlantica essential oils, from himachalenes mixture in five steps. Reactions conditions were optimized and structures of the obtained compounds were confirmed by IR, mass spectra, 1H, and 13C NMR. The synthesized compounds were investigated for potential activities on various isolated smooth muscles and against different neurotransmitters using molecular docking. The results show that the synthesized compounds display high affinities towards the active site of the protein 7B2W and the compounds exhibit promising activities on various isolated smooth muscles and against different neurotransmitters.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41598-023-44652-z.pdf

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