Vascular comorbidity is associated with decreased cognitive functioning in inflammatory bowel disease

Author:

Patel Ronak,Marrie Ruth Ann,Bernstein Charles N.,Bolton James M.,Graff Lesley A.,Marriott James J.,Figley Chase R.,Kornelsen Jennifer,Mazerolle Erin L.,Uddin Md Nasir,Fisk John D.,Bolton James,Graff Lesley,Kornelsen Jennifer,Mazerolle Erin,Patel Ronak,Figley Teresa D.,Helmick Carl A.,

Abstract

AbstractReports of cognitive impairment in inflammatory bowel disease (IBD) have been mixed. IBD and cardiovascular disease are often co-morbid, yet it remains unknown whether vascular comorbidity confers a risk for decreased cognitive functioning, as observed in other populations. Participants with IBD were recruited from a longitudinal study of immune-mediated disease. Participants were administered a standardized neuropsychological test protocol, evaluating information processing speed, verbal learning and memory, visual learning and memory, and verbal fluency/executive function. Cognitive test scores were standardized using local regression-based norms, adjusting for age, sex, and education. Vascular risk was calculated using a modified Framingham Risk Score (FRS). We tested the association between FRS and cognitive test scores using a quantile regression model, adjusting for IBD type. Of 84 IBD participants, 54 had ulcerative colitis and 30 had Crohn’s disease; mean (SD) age was 53.36 (13.95) years, and a high proportion were females (n = 58). As the risk score (FRS) increased, participants demonstrated lower performance in information processing speed (β = − 0.12; 95% CI − 0.24, − 0.006) and verbal learning (β = − 0.14; 95% CI − 0.28, − 0.01) at the 50th percentile. After adjusting for IBD type and disease activity, higher FRS remained associated with lower information processing speed (β = − 0.14; 95% CI − 0.27, − 0.065). Vascular comorbidity is associated with lower cognitive functioning in persons with IBD, particularly in the area of information processing speed. These findings suggest that prevention, identification, and treatment of vascular comorbidity in IBD may play a critical role for improving functional outcomes in IBD.

Funder

Waugh Family Foundation MS Society of Canada Operating Grant

Canadian Institutes of Health Research

Crohn’s and Colitis Canada

Waugh Family Chair in Multiple Sclerosis

Bingham Chair in Gastroenterology

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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