Author:
Larese Filon Francesca,Rui Francesca,Ronchese Federico,De Michieli Paola,Negro Corrado
Abstract
AbstractTo evaluate the incidence of COVID-19 infection in health care workers from the start of the COVID-19 pandemic in NE Italy, vaccination with BNT162b2. This was a retrospective cohort study. Healthcare workers were routinely tested for SARS-CoV-2 infection using real-time polymerase chain reaction tests in nasopharyngeal swabs. Logistic regression was used to calculate the incidence rate ratios (IRRs) of the factors associated with COVID-19. A total of 4251 workers were followed up, and the prevalence of COVID-19 was 13.6%. In March 2021 the incidence of infection was 4.88 and 103.55 cases for 100,000 person-days in vaccinated and non-vaccinated workers, respectively, with an adjusted IRRs of 0.05 (95% CI 0.02–0.08). Our study evaluated the monthly incidence in health care workers in Trieste hospitals before and after vaccination, finding an estimated vaccine effectiveness of 95% in health care workers routinely tested.
Publisher
Springer Science and Business Media LLC
Reference20 articles.
1. Piapan, L. et al. COVID-19 outbreak in healthcare workers in hospitals in Trieste, North-east Italy. J. Hosp. Infect. 106(3), 626–628. https://doi.org/10.1016/j.jhin.2020.08.012 (2020).
2. Istituto Superiore di Sanità (ISS). Speciale COVID-19 vaccini https://www.iss.it/vaccini-covid-19 (accessed 2 Feb 2021).
3. Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383(27), 2603–2615. https://doi.org/10.1056/NEJMoa2034577 (2020).
4. US Food and Drug Agency. Emergency Use Authorization for Pfizer-BioNTech COVID-19 vaccine. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccine (accessed 25 Feb 2021).
5. European Medicines Agency. EMA recommends first COVID-19 vaccine for authorisation in the EU. https://www.ema.europa.eu/en/news/ema-recommends-first-covid-19-vaccine-authorisation-eu (accessed 8 Feb 2021).