Author:
Lu Liesheng,Liu Changqin,Liu Kunpeng,Shi Chenzhang,Liu Zhongchen,Jiang Xun,Wang Feng
Abstract
AbstractAssociations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently published genome-wide association studies (GWASs) including a total of 1,190,502 people from Europe were used as our data source. Inverse variance weighting (OR = 1.120, 95% CI 1.029–1.219) and weighted median (OR = 1.112, 95% CI 1.000–1.236) analyses revealed a causal effect between LST and IBS. There was no evidence of pleiotropy in the sensitive analysis (MR-Egger, p = 0.139). After removing potentially confounding single nucleotide polymorphisms (SNPs), similar results were found using inverse variance weighting (OR = 1.131, 95% CI 1.025–1.248) and weighted median (OR = 1.151, 95% CI 1.020–1.299), as well as in the validation analyses using inverse variance weighting (OR = 1.287, 95% CI 0.996–1.662). This study provided support for a possible causal relationship between leisure screen time and IBS.
Publisher
Springer Science and Business Media LLC