Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure
Author:
Funder
British Heart Foundation
RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-42592-1.pdf
Reference82 articles.
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2. Borlaug, B. A. et al. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 114, 2138–2147, https://doi.org/10.1161/CIRCULATIONAHA.106.632745 (2006).
3. Raake, P. W. J. et al. AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. Eur Heart J. https://doi.org/10.1093/eurheartj/ehr447 (2012).
4. El-Armouche, A., Pamminger, T., Ditz, D., Zolk, O. & Eschenhagen, T. Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts. Cardiovasc Res 61, 87–93, https://doi.org/10.1016/j.cardiores.2003.11.005 (2004).
5. Nikolaev, V. O. et al. β2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 327, 1653–1657, https://doi.org/10.1126/science.1185988 (2010).
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