Author:
Leclerc Pierre,Ray Cedric,Mahieu-Williame Laurent,Alston Laure,Frindel Carole,Brevet Pierre-François,Meyronet David,Guyotat Jacques,Montcel Bruno,Rousseau David
Abstract
AbstractGliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX fluorescence measurements are a clinical standard, but expert-based classification models still lack sensitivity and specificity. Here a fully automatic clustering method is proposed to discriminate glioma margin. This is obtained from spectroscopic fluorescent measurements acquired with a recently introduced intraoperative set up. We describe a data-driven selection of best spectral features and show how this improves results of margin prediction from healthy tissue by comparison with the standard biomarker-based prediction. This pilot study based on 10 patients and 50 samples shows promising results with a best performance of 77% of accuracy in healthy tissue prediction from margin tissue.
Funder
Agence Nationale de la Recherche
Clara
Publisher
Springer Science and Business Media LLC
Cited by
16 articles.
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