Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53-Reference-Cited by-同舟云学术

Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53

Published:2019-06-28 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Kamagata Kiyoto,Mano Eriko,Itoh Yuji,Wakamoto Takuro,Kitahara Ryo^ORCID,Kanbayashi Saori,Takahashi Hiroto,Murata Agato,Kameda Tomoshi

Funder

MEXT | Japan Society for the Promotion of Science

the Research Program of "Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials" in "Network Joint Research Center for Materials and Devices"

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-44688-0.pdf

Reference52 articles.

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2. Dunker, A. K. & Uversky, V. N. Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors. Curr. Opin. Pharmacol. 10, 782–788 (2010).

3. Sammak, S. & Zinzalla, G. Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs). Prog. Biophys. Mol. Biol. 119, 41–46 (2015).

4. Ruan, H., Sun, Q., Zhang, W., Liu, Y. & Lai, L. Targeting intrinsically disordered proteins at the edge of chaos. Drug Discov Today 1, 217–227 (2019).

5. Jin, F., Yu, C., Lai, L. & Liu, Z. Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput. Biol. 9, e1003249 (2013).

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