The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors
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Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-06698-8.pdf
Reference39 articles.
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2. Shin, J. M., Munson, K., Vagin, O. & Sachs, G. The gastric HK-ATPase: structure, function, and inhibition. Pflugers Arch. 457, 609–622 (2009).
3. Besancon, M., Simon, A., Sachs, G. & Shin, J. M. Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents. J. Biol. Chem. 272, 22438–22446 (1997).
4. Shin, J. M., Cho, Y. M. & Sachs, G. Chemistry of covalent inhibition of the gastric (H+,K+)-ATPase by proton pump inhibitors. J. Am. Chem. Soc. 126, 7800–7811 (2004).
5. Arikawa, Y. et al. Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs). Bioorg. Med. Chem. Lett. 25, 2037–2040 (2015).
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