Author:
Yang Jianrong,Chen Chunxia,Chen Wan,Huang Luying,Fu Zhao,Ye Kun,Lv Liwen,Nong Zhihuang,Zhou Xing,Lu Wensheng,Zhong Mei
Abstract
AbstractPulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics and untargeted metabolomics were used to screen disease-related signaling pathways through clustering and enrichment analysis of the differential expression of proteins and metabolites. The main imaging features were lesions located in the bilateral lower lobes and involvement in five lobes. The closed association pathways were FcγR-mediated phagocytosis, PPAR signaling, TRP-inflammatory pathways, and the urea cycle. Our results provide evidence for the detection of serum biomarkers and targeted therapy in patients with Covid-19.
Funder
National Natural Science Foundation of China
the Guangxi Natural Science Foundation
the Guangxi Medical and Health Appropriate Technology Research and Development Project
Shanxi Health Research Project
Publisher
Springer Science and Business Media LLC
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