Antidepressant–like effects of fish, krill oils and Vit B12 against exposure to stress environment in mice models: current status and pilot study

Author:

Zadeh-Ardabili Parastoo Mojtahed,Rad Sima Kianpour,Rad Soheila Kianpour,Movafagh Abolfazl

Abstract

AbstractOxidative stress has significant role in pathophysiology of any kind of depression through actions of free radicals, non-radical molecules, and unbalancing antioxidant systems in body. In the current study, antidepressant responses of fish oil (FO), Neptune krill oil (NKO), vitamin B12 (Vit B12), and also imipramine (IMP) as the reference were studied. Natural light was employed to induce stress in the animals followed by oral administration of the drugs for 14 days. The antidepressant effect was assessed by tail suspension test (TST) and forced swimming test (FST), antioxidant enzymes and oxidative stress markers were then measured in the brain tissue of the animals. The administration of FO and NKO could significantly reduce the immobility of the animals; while, increasing climbing and swimming time compared to the normal saline in CUS-control group in TST and FST, similarly to IMP but not with Vit B12. Vit B12 could not effect on SOD activity and H2O2level, but, cause decrease of the malondialdihydric (MDA) level and CAT activity, as well as increased the GPx and GSH activities. The rest treatments led to decrease of MDA, H2O2levels and CAT activity and increase of GPx, SOD, GSH activities.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference51 articles.

1. Andrade, L. et al. Cross-national comparisons of the prevalences and correlates of mental disorders. Bull World Health Organ. 78, 413–425 (2000).

2. Wittchen, H. U., Nelson, C. B. & Lachner, G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychol Med. 28, 109–126 (1998).

3. Lee, S., Liu, H. P., Lin, W.-Y., Guo, H. & Lu, B. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. Jo Neurosci. 30, 16959–16969 (2010).

4. Khan, K., Najmi, A. K. & Akhtar, M. A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice. Drug Res. 69(07), 392–400 (2018).

5. Gong, M. F. et al. Attenuation of ethanol abstinence-induced anxiety-and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacol. 234, 3143–3151 (2017).

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