Author:
Owen Joshua,Negussie Ayele H.,Burks Scott R.,Delgado Jose,Mikhail Andrew S.,Rivera Jocelyne,Pritchard William F.,Karanian John W.,Stride Eleanor,Frank Joseph A.,Wood Bradford J.
Abstract
AbstractTransarterial chemoembolization (TACE) is an image-guided minimally invasive treatment for liver cancer which involves delivery of chemotherapy and embolic material into tumor-supplying arteries to block blood flow to a liver tumor and to deliver chemotherapy directly to the tumor. However, the released drug diffuses only less than a millimeter away from the beads. To enhance the efficacy of TACE, the development of microbubbles electrostatically bound to the surface of drug-eluting beads loaded with different amounts of doxorubicin (0–37.5 mg of Dox/mL of beads) is reported. Up to 400 microbubbles were bound to Dox-loaded beads (70–150 microns). This facilitated ultrasound imaging of the beads and increased the release rate of Dox upon exposure to high intensity focused ultrasound (HIFU). Furthermore, ultrasound exposure (1 MPa peak negative pressure) increased the distance at which Dox could be detected from beads embedded in a tissue-mimicking phantom, compared with a no ultrasound control.
Funder
National Institutes of Health
Intramural Research Program of the National Institutes of Health
NIH Ox Cam Program
Publisher
Springer Science and Business Media LLC
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