Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
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Published:2021-01-13
Issue:1
Volume:11
Page:
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ISSN:2045-2322
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Container-title:Scientific Reports
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language:en
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Short-container-title:Sci Rep
Author:
Hajimohammadi Bahador, Eslami GildaORCID, Zandi Hengameh, Ehrampoush Mohammad Hassan, Naimi Azar, Derakhshan Maryam, Hedayat Pegah, Fallahi Roozbeh, Fallahzadeh Hossein, Rezvani Mohammad Ebrahim, Vakili Mahmoud, Moshtaghioun Seyed Mohammad, Athari Seyyed Shamsadin, Asadi-Yousefabad Seyedeh Leili, Hosseini Saeedeh Sadat, Shirdeli Mehrnoush, Ahmadian Salman, Mortazavi Shirin, Loni Elahe, Ajamein Vahid, Ahmadi Amin, Askari Vahideh
Abstract
AbstractRice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague–Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.
Funder
Vice-Presidency for Science and Technology of Iran
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
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