Coffee consumption and associations with blood pressure, LDL-cholesterol and echocardiographic measures in the general population

Author:

Senftinger Juliana,Nikorowitsch Julius,Borof Katrin,Ojeda Francisco,Aarabi Ghazal,Beikler Thomas,Mayer Carola,Behrendt Christian-Alexander,Walther Carolin,Zyriax Birgit-Christiane,Twerenbold Raphael,Blankenberg Stefan,Wenzel Jan-Per

Abstract

AbstractCoffee, next to water the most widespread beverage, is attributed both harmful and protective characteristics concerning cardiovascular health. This study aimed to evaluate associations of coffee consumption with cardiac biomarkers, echocardiographic, electrocardiographic parameters and major cardiovascular diseases. We performed a cross-sectional analysis of 9009 participants of the population-based Hamburg City Health Study (HCHS), enrolled between 2016 and 2018 median age 63 [IQR: 55; 69] years. Coffee consumption was classified into three groups: < 3 cups/day (low), 3–4 cups/day (moderate), > 4 cups/day (high). In linear regression analyses adjusted for age, sex, body mass index, diabetes, hypertension, smoking, and additives, high coffee consumption correlated with higher LDL-cholesterol (β = 5.92; 95% CI 2.95, 8.89; p < 0.001). Moderate and high coffee consumption correlated with lower systolic (β = − 1.91; 95% CI − 3.04, − 0.78; p = 0.001; high: β = − 3.06; 95% CI − 4.69, − 1.44; p < 0.001) and diastolic blood pressure (β = − 1.05; 95% CI − 1.67, − 0.43; p = 0.001; high: β = − 1.85; 95% CI − 2.74, − 0.96; p < 0.001). Different levels of coffee consumption did neither correlate with any investigated electrocardiographic or echocardiographic parameter nor with prevalent major cardiovascular diseases, including prior myocardial infarction and heart failure. In this cross-sectional analysis, high coffee consumption correlated with raised LDL-cholesterol levels and lower systolic and diastolic blood pressure. However, major cardiovascular diseases including heart failure and its diagnostic precursors were not associated with coffee consumption, connoting a neutral role of coffee in the context of cardiovascular health.

Funder

SIEMENS

Amgen

Astra Zeneca

Abbott

Roche

Singulex and Thermo Scientific BRAHMS

Thermo Fisher

Universitätsklinikum Hamburg-Eppendorf (UKE)

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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