Drug treatment efficiency depends on the initial state of activation in nonlinear pathways

Author:

Doldán-Martelli Victoria,Míguez David G.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference35 articles.

1. Doldán-Martelli, V., Guantes, R. & Míguez, D. G. A mathematical model for the rational design of chimeric ligands in selective drug therapies. CPT: pharmacometrics & systems pharmacology 2, e26 (2013).

2. Ruiz-Herrero, T., Estrada, J., Guantes, R. & Miguez, D. G. A Tunable Coarse-Grained Model for Ligand-Receptor Interaction. PLoS Computational Biology 9 (2013).

3. Míguez, D. G. Network nonlinearities in drug treatment. Interdisciplinary Sciences: Computational Life Sciences 5, 85–94 (2013).

4. Doldán-Martelli, V. & Míguez, D. G. Synergistic interaction between selective drugs in cell populations models. PloS one 10, e0117558 (2015).

5. Tyson, J. J., Chen, K. C. & Novak, B. Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Current Opinion in Cell Biology 15, 221–231 (2003).

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