Abstract
AbstractRed bone marrow and brain tissue are highly radiosensitive in children. We investigate the relationship between childhood computed tomography (CT) exposure and leukaemia, intracranial malignancy and lymphoma. All participants in the study were aged less than 16 years. A total of 1,479 patients in the leukaemia group, 976 patients in the intracranial malignancy group and 301 patients in the lymphoma group were extracted from the Catastrophic Illness Certificate Database in Taiwan as the disease group. In total, 126,677 subjects were extracted from the Longitudinal Health Insurance Database 2010 of the Taiwan National Health Insurance Research Database as the non-disease group. The odds ratios (ORs) and 95% confidence intervals (CIs) for childhood CT exposure and times of childhood CT were estimated. Childhood CT exposure was correlated to the intracranial malignancy group in both one-year (OR = 1.95, 95% CI 1.40–2.71, p < 0.001) and two-year (OR = 1.56, 95% CI 1.04–2.33, p = 0.031) exclusion periods. The time of childhood CT was also correlated to intracranial malignancy in both one-year (OR = 1.69, 95% CI 1.34–2.13, p < 0.001) and two-year (OR = 1.55, 95% CI 1.17–2.04, p = 0.002) exclusion periods. The results indicated that childhood CT exposure was correlated with an increased risk of future intracranial malignancy.
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. Berrington de Gonzalez, A. et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch. Intern. Med. 169, 2071–2077, https://doi.org/10.1001/archinternmed.2009.440 (2009).
2. Asha, S. et al. Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a panscan protocol. Emerg. Med. Australas. 24, 43–51, https://doi.org/10.1111/j.1742-6723.2011.01504.x (2012).
3. Radiation Health Committee. Australian radiation protection and nuclear safety agency. Exposure of humans to ionizing radiation for research purposes, https://www.arpansa.gov.au/sites/g/files/net3086/f/legacy/pubs/rps/rps8.pdf (2005).
4. Pearce, M. S. et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380, 499–505, https://doi.org/10.1016/S0140-6736(12)60815-0 (2012).
5. Mathews, J. D. et al. Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 346, f2360, https://doi.org/10.1136/bmj.f2360 (2013).
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