Author:
Cohen Isaac V.,Makunts Tigran,Moumedjian Talar,Issa Masara A.,Abagyan Ruben
Abstract
Abstract
Chloroquine (CQ) and hydroxychloroquine (HCQ) are on the World Health Organization’s List of Essential Medications for treating non-resistant malaria, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, both drugs are currently used off-label in hospitals worldwide and in numerous clinical trials for the treatment of SARS-CoV-2 infection. However, CQ and HCQ use has been associated with cardiac side effects, which is of concern due to the higher risk of COVID-19 complications in patients with heart related disorders, and increased mortality associated with COVID-19 cardiac complications. In this study we analyzed over thirteen million adverse event reports form the United States Food and Drug Administration Adverse Event Reporting System to confirm and quantify the association of cardiac side effects of CQ and HCQ. Additionally, we identified several confounding factors, including male sex, NSAID coadministration, advanced age, and prior diagnoses contributing to drug related cardiotoxicity. These findings may help guide therapeutic decision making and ethical trial design for COVID-19 treatment.
Publisher
Springer Science and Business Media LLC
Reference50 articles.
1. Devaux, C. A., Rolain, J.-M., Colson, P. & Raoult, D. New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19?. Int. J. Antimicrob. Agents
https://doi.org/10.1016/j.ijantimicag.2020.105938
(2020).
2. Colson, P., Rolain, J.-M. & Raoult, D. Chloroquine for the 2019 novel coronavirus SARS-CoV-2. Int. J. Antimicrob. Agents 55, 105923 (2020).
3. Al-Bari, M. A. A. Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases. Pharmacol. Res. Perspect. 5, e00293 (2017).
4. Plaquenil [package insert]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC (2006).
5. Aralen [package insert]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC (2013).
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献