Author:
da Costa Teixeira Leonardo Augusto,Avelar Nubia Carelli Pereira,Peixoto Marco Fabrício Dias,Parentoni Adriana Netto,Santos Jousielle Marcia dos,Pereira Fabiana Souza Máximo,Danielewicz Ana Lúcia,Leopoldino Amanda Aparecida Oliveira,Costa Sabrina Paula,Arrieiro Arthur Nascimento,Soares Luana Aparecida,da Silva Lage Vanessa Kelly,Prates Ana Caroline Negreiro,Taiar Redha,de Carvalho Bastone Alessandra,Oliveira Vinicius Cunha de,Oliveira Murilo Xavier,Costa Henrique Silveira,Nobre Juliana Nogueira Pontes,Brant Franciane Pereira,Duarte Tamiris Campos,Figueiredo Pedro Henrique Scheidt,Mendonça Vanessa Amaral,Lacerda Ana Cristina Rodrigues
Abstract
AbstractIn recent years, studies have found that Sarcopenia alters inflammatory biomarkers. However, the behavior of inflammatory biomarkers at different stages of Sarcopenia is not well understood. This study aimed to compare a broad panel of inflammatory biomarkers in older women at different stages of Sarcopenia. The study included 71 Brazilian community-dwelling older women. Muscle Strength was assessed by using handgrip strength (Jamar dynamometer). The Short Physical Performance Battery (SPPB) was performed to assess the physical performance, and body composition was assessed by DEXA. Sarcopenia was diagnosed and classified according to the EWGSOP2 criteria. Blood was drawn, and inflammatory biomarkers associated with Sarcopenia (IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF, adiponectin, leptin, resistin, BDNF, sTNFr-1 and sTNFr-2) was analysed. After diagnosis and classification of sarcopenia, 45% of women did not present Sarcopenia (NS, N = 32), 23.9% were diagnosed with Sarcopenia Probable (SP, N = 17), 19,7% with Sarcopenia Confirmed (SC, N = 14), and 11.3% with Severe Sarcopenia (SS, N = 8). The analysis of inflammatory biomarkers revealed that the more advanced the stage of Sarcopenia, the higher the levels of BDNF, IL-8, sTNFr-1, and sTNFr-2. The assessment of BDNF, IL-8, sTNFr-1, and sTNFr-2 levels may be an adjuvant tool in diagnosis and severity classification of Sarcopenia in older Brazilian women.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Publisher
Springer Science and Business Media LLC