Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells-Reference-Cited by-同舟云学术

Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

Published:2017-12 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Muraki Katsuhiko,Ohnishi Kaori,Takezawa Akiho,Suzuki Hiroka,Hatano Noriyuki,Muraki Yukiko,Hamzah Nurasyikin,Foster Richard,Waldmann Herbert,Nussbaumer Peter^ORCID,Christmann Mathias,Bon Robin S.,Beech David J.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-17303-3.pdf

Reference33 articles.

1. Ratnayake, R., Covell, D., Ransom, T. T., Gustafson, K. R. & Beutler, J. A. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Org. Lett. 11, 57–60 (2009).

2. Sourbier, C. et al. Englerin A stimulates PKCtheta to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell 23, 228–237 (2013).

3. Akbulut, Y. et al. (−)Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew. Chem. Int. Ed. Engl. 54, 3787–3791 (2015).

4. Ludlow, M. J. et al. (−)Englerin A-evoked cytotoxicity is mediated by Na+ influx and counteracted by Na+/K+-ATPase. J. Biol. Chem. 292, 723–731 (2017).

5. Carson, C. et al. Englerin A agonizes the TRPC4/C5 cation channels to inhibit tumor cell line proliferation. PLoS One 10, e0127498, https://doi.org/10.1371/journal.pone.0127498 (2015).

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