Author:
Contente Martina L.,Marzuoli Irene,Iding Hans,Wetzl Dennis,Puentener Kurt,Hanlon Steven P.,Paradisi Francesca
Abstract
AbstractAlcohol oxidation for the generation of carbonyl groups, is an essential reaction for the preparation of fine chemicals. Although a number of chemical procedures have been reported, biocatalysis is a promising alternative for more sustainable and selective processes. To speed up the discovery of novel (bio)catalysts for industrial applications, efficient screening approaches need to be established. Here, we report on an enzyme-mediated alcohol oxidation screening platform to rapidly detect the activities and selectivities of three classes of biocatalysts; ketoreductases (KREDs), alcohol oxidases (AlcOXs) and laccase-mediator systems (LMSs) with diverse substrates.
Publisher
Springer Science and Business Media LLC
Reference22 articles.
1. Organic Synthesis by Oxidation with Metal Compounds (Eds: W. J. Mijs, C.R.H.I. de Jonge). Plenum, New York (1986).
2. Noyori, R. & Ohkuma, T. Asymmetric catalysis by architectural and functional molecular engineering: practical chemo- and stereoselective hydrogenation of ketones. Angew. Chem. Int. Ed. 40, 40–73 (2001).
3. de Graauw, C. F., Peters, J. A., van Bekkun, H. & Huskens, J. Meerwein-Ponndorf-Verley reductions and oppenauer oxidations: an integrated approach. Synthesis 1994, 1007–1017 (1994).
4. Hudlicky, M. Oxidation in Organic Chemistry, ACS monograph 186, Washington DC (1990).
5. Hinzmann, A. et al. Selective TEMPO-oxidation of alcohols to aldehydes in alternative organic solvents. EurJoc 16, 2399–2408 (2020).
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献