Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-16089-8.pdf
Reference51 articles.
1. Pakos-Zebrucka, K. et al. The integrated stress response. EMBO reports 17, 1374–1395, https://doi.org/10.15252/embr.201642195 (2016).
2. Bonnet, M. C., Daurat, C., Ottone, C. & Meurs, E. F. The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cell Signal 18, 1865–1875 (2006).
3. Gil, J. et al. TRAF family proteins link PKR with NF-kappa B activation. Mol Cell Biol 24, 4502–4512 (2004).
4. Lu, B. et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488, 670–674 (2012).
5. Yim, H. C. et al. The kinase activity of PKR represses inflammasome activity. Cell research 26, 367–379, https://doi.org/10.1038/cr.2016.11 (2016).
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