Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-08063-1.pdf
Reference35 articles.
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2. Jorritsma, S. H., Gowans, E. J., Grubor-Bauk, B. & Wijesundara, D. K. Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines. Vaccine 34, 5488–5494 (2016).
3. Gargett, T. et al. Induction of antigen-positive cell death by the expression of perforin, but not DTa, from a DNA vaccine enhances the immune response. Immunol Cell Biol 92, 359–367 (2014).
4. Gummow, J. et al. A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice. J Virol 89, 7991–8002 (2015).
5. Grubor-Bauk, B. et al. Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs. Gene Ther 23, 26–37 (2016).
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