Author:
Carreras-Badosa Gemma,Maslovskaja Julia,Vaher Helen,Pajusaar Laura,Annilo Tarmo,Lättekivi Freddy,Hübenthal Matthias,Rodriguez Elke,Weidinger Stephan,Kingo Külli,Rebane Ana
Abstract
AbstractAtopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory skin diseases with heterogeneous molecular backgrounds. MicroRNAs (miRNAs) contribute to either development or regulation of many immune system related diseases. Only few miRNA profiling studies are available for AD and no comparisons between AD and PV skin miRNA profiles have been performed recently. We conducted a miRNA profiling analysis of skin, as well as serum, from adult AD and PV patients and control individuals. 130 miRNAs were differentially expressed in AD skin, of which 77 were common differentially expressed in AD and PV. No differentially expressed miRNAs were detected in serum. Pathway analyses revealed differentially expressed miRNAs to potentially target immune-system related pathways, including TNF-α, IL-2/STAT4 and IL-6/JAK/STAT3. Additional genetic analysis of published AD GWAS dataset detected association of several target genes of differentially expressed miRNAs in skin. Moreover, miR-28-5p, miR-31-5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. All validated miRNAs were reliable predictive markers for AD or PV. In conclusion, miRNA expression pattern in the skin of adult AD patients is highly similar to that of PV with multiple differentially expressed miRNAs potentially involved in the regulation of immune responses in AD and PV.
Publisher
Springer Science and Business Media LLC
Reference64 articles.
1. Ständer, S. Atopic dermatitis. N. Engl. J. Med. 384(12), 1136–1143 (2021).
2. Billi, A. C., Gudjonsson, J. E. & Voorhees, J. J. Psoriasis: Past, present, and future. J. Investig. Dermatol. 139(11), e133–e142 (2019).
3. Akdis, C. A. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?. Nat. Rev. Immunol. Nat. Res. 1, 1 (2021).
4. Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. & Barker, J. N. W. N. Psoriasis. The Lancet 397(10281), 1301–1315 (2021).
5. Bieber, T. et al. Abrocitinib versus placebo or dupilumab for atopic dermatitis. N. Engl. J. Med. 384(12), 1101–1112 (2021).
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