Synthesis and anti-inflammatory activities of two new N-acetyl glucosamine derivatives-Reference-Cited by-同舟云学术

Synthesis and anti-inflammatory activities of two new N-acetyl glucosamine derivatives

Published:2024-05-14 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Zhang Zhichang,Wang Weicheng,Xu Peng,Cui Quanjun,Yang Xinlin,Hassan Ameer E.

Abstract

AbstractN-acetyl glucosamine (NAG) is a natural amino sugar found in various human tissues with previously described anti-inflammatory effects. Various chemical modifications of NAG have been made to promote its biomedical applications. In this study, we synthesized two bi-deoxygenated NAG, BNAG1 and BNAG2 and investigated their anti-inflammatory properties, using an in vivo and in vitro inflammation mouse model induced by lipopolysaccharide (LPS). Among the parent molecule NAG, BNAG1 and BNAG2, BNAG1 showed the highest inhibition against serum levels of IL-6 and TNF α and the leukocyte migration to lungs and peritoneal cavity in LPS challenged mice, as well as IL-6 and TNF α production in LPS-stimulated primary peritoneal macrophages. BNAG2 displayed an anti-inflammatory effect which was comparable to NAG. These findings implied potential application of these novel NAG derivatives, especially BNAG1, in treatment of certain inflammation-related diseases.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-024-61780-2.pdf

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