Author:
Xu Ying,Ren Yan,Zou Wenli,Ji Shuiyu,Shen Wei
Abstract
AbstractErectile dysfunction (ED) is the most prevalent consequences in men with diabetes mellitus (DM). Recent studies demonstrates that neutrophil extracellular traps (NETs) play important roles in DM and its complications. Nevertheless, whether NETs are involved in ED remains unknown. This work intended to explore the role and mechanisms of NETs in ED in the context of DM. Here, we observed that NET generation and pyroptosis were promoted in DM rats with ED compared with controls. Mechanistically, NETs facilitated NLRP3 inflammasome activation and subsequently triggered pyroptosis under high glucose stress, ultimately leading to ED. Intriguingly, DNase I (a NET degrading agent) alleviated ED and corpus cavernosum injury in DM rats. Overall, NETs might induce ED in DM by promoting NLRP3-mediated pyroptosis in the corpus cavernosum.
Funder
The General Project of the Medical and Health of Zhejiang Province
The Project of Scientific Research Foundation of Chinese Medicine
Publisher
Springer Science and Business Media LLC
Reference44 articles.
1. Debasis, B., Ann, S. P., Bhimrao, F. S. & Sonia, M. Erectile dysfunction: A review on prevalence, perceptions, diagnosis and management in India. J. Assoc. Phys. India 68, 57–61 (2020).
2. Wang, C. M., Wu, B. R., Xiang, P., Xiao, J. & Hu, X. C. Management of male erectile dysfunction: From the past to the future. Front. Endocrinol. (Lausanne) 14, 1148834. https://doi.org/10.3389/fendo.2023.1148834 (2023).
3. Ruan, Z. et al. Association between dietary inflammation and erectile dysfunction among US adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001–2004. Front. Nutr. 9, 930272. https://doi.org/10.3389/fnut.2022.930272 (2022).
4. Ma, Z. et al. N-acetylcysteine improves diabetic associated erectile dysfunction in streptozotocin-induced diabetic mice by inhibiting oxidative stress. J. Cell Mol. Med. 26, 3527–3537. https://doi.org/10.1111/jcmm.17394 (2022).
5. Yu, Y. et al. Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes. BMC Endocr. Disord. 20, 158. https://doi.org/10.1186/s12902-020-00597-2 (2020).