Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways
Author:
Funder
Israel Science Foundation (ISF)
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-29215-x.pdf
Reference61 articles.
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2. Lopez-Sanchez, I. et al. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. FEBS letters 588, 692–700, https://doi.org/10.1016/j.febslet.2014.01.040 (2014).
3. Monsalve, D. M. et al. VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage. Biochimica et biophysica acta 1863, 760–769, https://doi.org/10.1016/j.bbamcr.2016.02.005 (2016).
4. Moura, D. S. et al. Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Scientific reports 6, 28532, https://doi.org/10.1038/srep28532 (2016).
5. Salzano, M., Sanz-Garcia, M., Monsalve, D. M., Moura, D. S. & Lazo, P. A. VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage. Epigenetics 10, 373–383, https://doi.org/10.1080/15592294.2015.1028708 (2015).
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