Author:
Clark Julia,Yakob Laith,Douno Moussa,Lamine Joseph,Magassouba N.’Faly,Fichet-Calvet Elisabeth,Mari-Saez Almudena
Abstract
AbstractLassa fever (LF) is a viral haemorrhagic fever endemic in West Africa and spread primarily by the multimammate rat, Mastomys natalensis. As there is no vaccine, reduction of rodent-human transmission is essential for disease control. As the household is thought to be a key site of transmission, understanding domestic risk factors for M. natalensis abundance is crucial. Rodent captures in conjunction with domestic surveys were carried out in 6 villages in an area of rural Upper Guinea with high LF endemicity. 120 rodent traps were set in rooms along a transect in each village for three nights, and the survey was administered in each household on the transects. This study was able to detect several domestic risk factors for increased rodent abundance in rural Upper Guinea. Regression analysis demonstrated that having > 8 holes (RR = 1.8 [1.0004–3.2, p = 0.048), the presence of rodent burrows (RR = 2.3 [1.6–3.23, p = 0.000003), and being in a multi-room square building (RR = 2.0 [1.3–2.9], p = 0.001) were associated with increased rodent abundance. The most addressable of these may be rodent burrows, as burrow patching is a relatively simple process that may reduce rodent entry. Further study is warranted to explicitly link domestic rodent abundance to LF risk, to better characterize domestic risk factors, and to evaluate how household rodent-proofing interventions could contribute to LF control.
Funder
Deutsche Forschungsgemeinschaft
Robert Koch-Institut
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Houlihan, C. & Behrens, R. Lassa fever. Br. Med. J. Publ. Group 12, 2 (2017).
2. Frame, J. D., Baldwin, J. M., Gocke, D. J. & Troup, J. M. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. Am. J. Trop. Med. Hyg. 19, 670–676. https://doi.org/10.4269/ajtmh.1970.19.670 (1970).
3. Buckley, S. M. Lassa fever a new virus disease of man from West Africa. III. Isolation and characterization of the virus. Am. J. Trop. Med. Hyg. 19, 680–691 (1970).
4. Fichet-Calvet, E. & Rogers, D. J. Risk maps of Lassa fever in West Africa. PLoS Negl. Trop. Dis. 3, e388. https://doi.org/10.1371/journal.pntd.0000388 (2009).
5. JB, M. Lassa Fever. Emergence and Control of Rodent-Borne viral diseases. (1999).
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