Author:
Robert Thomas,Lano Guillaume,Resseguier Noémie,Bobot Mickaël,Bouchouareb Dammar,Burtey Stéphane,de Lamballerie Xavier,Dhorne Jean,Dussol Bertrand,Duval Ariane,Faraut Julien,Fourié Toscane,Giaime Philippe,Hallah Mourad,Jaubert Dominique,Jéhel Océane,Legris Tristan,Liotatis Stéphane,Moal Valérie,Ninove Laetitia,Pedinielli Nathalie,Pelletier Marion,Romeu-Giannoli Manon,Saba Mariela,Sallée Marion,Samson Laurent,Saveanu Adriana,Scarfoglière Violaine,Sebahoun Pascale,Vial Romain,Von Kotze Clarissa,Brunet Philippe,Lebrun Gaëtan,Bataille Stanislas,Jourde-Chiche Noémie
Abstract
AbstractHemodialysis (HD) patients are at risk for severe COVID-19 and cannot comply with social distancing. SARS-COV2 seroprevalence in French patients and caregivers after the first wave of COVID-19 is unknown. SeroCOVIDial is a prospective study conducted between June and December 2020. SARS-COV2 seroprevalence was evaluated by a rapid serological test (BIOSYNEX) in HD patients and caregivers, and the presence or not of anti-SARS-COV2 neutralizing or non-neutralizing antibodies in patients was also determined by ELISA and seroneutralization. In June 2020, 451 HD patients and 238 caregivers were included. Overall SARS-COV2 seroprevalence was 8.4% (patients) and 6.7% (caregivers), and was 87.1% (patients) and 90.0% (caregivers) in participants with a previously documented SARS-COV2 infection. Overall seroprevalence reached 13.8% (patients) and 12.6% (caregivers) following the second epidemic wave. During the follow-up, 38 (8.4%) patients died (9 of COVID-19). Among the 44 (10.6%) patients who became infected, only two were seropositive at M0. The levels of anti-SARS-COV2 antibodies decreased over time in patients and caregivers. The BIOSYNEX test showed 82.9% sensitivity and 97.7% specificity. Prevalence of anti-SARS-COV2 antibodies was low in HD patients and caregivers after the first epidemic wave but rose after the second wave. A rapid serological test showed good performances and could be useful for future monitoring of anti-SARS-COV2 antibodies.
Publisher
Springer Science and Business Media LLC