Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease

Author:

Jokela Heli,Hakkarainen Janne,Kätkänaho Laura,Pakarinen Pirjo,Ruohonen Suvi T.,Tena-Sempere Manuel,Zhang Fu-Ping,Poutanen Matti

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference37 articles.

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2. Austin, C. P. et al. The Knockout Mouse Project. Nat. Genet. 36, 921–924 (2004).

3. Zuniga, A. et al. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18, 1553–1564 (2004).

4. Pan, Y. et al. Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Sci. Rep. 6, 35970 (2016).

5. West, D. B. et al. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 12, 1–19 (2016).

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