Author:
de Almeida Maria Edilene M.,Alves Késsia Caroline Souza,de Vasconcelos Maria Gabriella Santos,Pinto Thiago Serrão,Glória Juliane Corrêa,Chaves Yury Oliveira,Neves Walter Luiz Lima,Tarragô Andrea Monteiro,de Souza Neto Júlio Nino,Astolfi-Filho Spartaco,Pontes Gemilson Soares,da Silva Balieiro Antônio Alcirley,Isticato Rachele,Ricca Ezio,Mariúba Luis André M.
Abstract
AbstractMalaria remains a widespread public health problem in tropical and subtropical regions around the world, and there is still no vaccine available for full protection. In recent years, it has been observed that spores of Bacillus subtillis can act as a vaccine carrier and adjuvant, promoting an elevated humoral response after co-administration with antigens either coupled or integrated to their surface. In our study, B. subtillis spores from the KO7 strain were used to couple the recombinant CSP protein of P. falciparum (rPfCSP), and the nasal humoral-induced immune response in Balb/C mice was evaluated. Our results demonstrate that the spores coupled to rPfCSP increase the immunogenicity of the antigen, which induces high levels of serum IgG, and with balanced Th1/Th2 immune response, being detected antibodies in serum samples for 250 days. Therefore, the use of B. subtilis spores appears to be promising for use as an adjuvant in a vaccine formulation.
Funder
Oswaldo Cruz Foundation, Brazil
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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