Author:
Xue Tianyuan,Stalmashonak Andrei,Chen Fu-Der,Ding Peisheng,Luo Xianshu,Chua Hongyao,Lo Guo-Qiang,Sacher Wesley D.,Poon Joyce K. S.
Abstract
AbstractWe have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.
Funder
Max-Planck-Gesellschaft
Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada
Max Planck Institute of Microstructure Physics
Publisher
Springer Science and Business Media LLC