Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-40810-4.pdf
Reference34 articles.
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2. Hayes, A. J., Benjamin, M. & Ralphs, J. R. Extracellular matrix in development of the intervertebral disc. Matrix Biol 20, 107–121 (2001).
3. Roughley, P. J. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine (Phila Pa 1976) 29, 2691–2699 (2004).
4. Smits, P. & Lefebvre, V. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development 130, 1135–1148 (2003).
5. Han, Y. & Lefebvre, V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol 28, 4999–5013, https://doi.org/10.1128/MCB.00695-08 (2008).
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