Effects of obesity on NK cells in a mouse model of postmenopausal breast cancer

Author:

Spielmann Julia,Mattheis Laura,Jung Juliane-Susanne,Rauße Henrik,Glaß Markus,Bähr Ina,Quandt Dagmar,Oswald Jana,Kielstein Heike

Abstract

AbstractObesity is a widely spread disease and a crucial risk factor for malign disorders, including breast cancer of women in the postmenopause. Studies demonstrated that in case of obesity crucial natural killer (NK) cell functions like combating tumor cells are affected. This study aims to analyze NK cells and NK cell receptor expression of obese mice in a model for postmenopausal breast cancer. Therefore, female BALB/c mice were fed either a high fat or a standard diet. Thereafter, ovaries were ectomized and a syngeneic and orthotopical injection of 4T1-luc2 mouse mammary tumor cells into the mammary adipose tissue pad was performed. Obese mice showed increased body weights and visceral fat mass as well as increased levels of leptin and IL-6 in plasma. Moreover, compared to the lean littermates, tumor growth was increased and the NKp46-expression on circulating NK cells was decreased. Furthermore, the activating NK cell receptor NKG2D ligand (MULT1) expression was enhanced in adipose tissue of obese tumor bearing mice. The present study gives novel insights into gene expression of NK cell receptors in obesity and aims to promote possible links of the obesity-impaired NK cell physiology and the elevated breast cancer risk in obese women.

Funder

Institut Danone Ernährung für Gesundheit e.V.

"Wilhelm Roux” program of the Martin Luther University Halle-Wittenberg

Projekt DEAL

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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