Gut dysbiosis in Thai intrahepatic cholangiocarcinoma and hepatocellular carcinoma

Author:

Pomyen Yotsawat,Chaisaingmongkol Jittiporn,Rabibhadana Siritida,Pupacdi Benjarath,Sripan Donlaporn,Chornkrathok Chidchanok,Budhu Anuradha,Budhisawasdi Vajarabhongsa,Lertprasertsuke Nirush,Chotirosniramit Anon,Pairojkul Chawalit,Auewarakul Chirayu U.,Ungtrakul Teerapat,Sricharunrat Thaniya,Phornphutkul Kannikar,Sangrajang Suleeporn,Loffredo Christopher A.,Harris Curtis C.,Mahidol Chulabhorn,Wang Xin Wei,Ruchirawat Mathuros,

Abstract

AbstractPrimary liver cancer (PLC), which includes intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC), has the highest incidence of all cancer types in Thailand. Known etiological factors, such as viral hepatitis and chronic liver disease do not fully account for the country’s unusually high incidence. However, the gut-liver axis, which contributes to carcinogenesis and disease progression, is influenced by the gut microbiome. To investigate this relationship, fecal matter from 44 Thai PLC patients and 76 healthy controls were subjected to whole-genome metagenomic shotgun sequencing and then analyzed by marker gene-based and assembly based methods. Results revealed greater gut microbiome heterogeneity in iCCA compared to HCC and healthy controls. Two Veillonella species were found to be more abundant in iCCA samples and could distinguish iCCA from HCC and healthy controls. Conversely, Ruminococcus gnavus was depleted in iCCA patients and could distinguish HCC from iCCA samples. High Veillonella genus counts in the iCCA group were associated with enriched amino acid biosynthesis and glycolysis pathways, while enriched phospholipid and thiamine metabolism pathways characterized the HCC group with high Blautia genus counts. These findings reveal distinct landscapes of gut dysbiosis among Thai iCCA and HCC patients and warrant further investigation as potential biomarkers.

Funder

The intramural research program of the Center for Cancer Research, National Cancer Institute of the United States

Thailand Science Research and Innovation (TSRI), Chulabhorn Research Institute

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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