Predictive factors and early biomarkers of response in multiple sclerosis patients treated with natalizumab

Author:

Dominguez-Mozo Maria Inmaculada,Perez-Perez Silvia,Villar Luisa María,Oliver-Martos Begoña,Villarrubia Noelia,Matesanz Fuencisla,Costa-Frossard Lucienne,Pinto-Medel María Jesús,García-Sánchez María Isabel,Ortega-Madueño Isabel,Lopez-Lozano Lorena,Garcia-Martinez Angel,Izquierdo Guillermo,Fernández Óscar,Álvarez-Cermeño Jose Carlos,Arroyo Rafael,Alvarez-Lafuente Roberto

Abstract

AbstractThere are an increasing number of treatments available for multiple sclerosis (MS). The early identification of optimal responders to individual treatments is important to achieve individualized therapy. With this aim, we performed a multicenter retrospective longitudinal study including 186 MS patients treated with natalizumab who were followed for 2 years. We analyzed the following variables at recruitment: sex, current age, age at disease onset, disease duration, EDSS, number of T2 and Gd + lesions, IgG and IgM oligoclonal bands, HLA class II (DR, DRB, DQA, DQB, and DRB1*15:01), IgG and IgM antibody titers against human herpesvirus 6 (HHV-6) and the antibody response to Epstein–Barr virus (EBV) through the measurement of the anti-EBNA-1 and anti-VCA IgG titers, in relation to clinical response (no relapses or disability progression), and to NEDA-3 (no evidence of disease activity in terms of clinical response and no changes in MRI scans either) after 2-years follow-up. Baseline EDSS score, baseline EBNA-1 IgG titers and percentage change of HHV6 IgG titers between baseline and 6 month visits were significantly different in clinical responders and in NEDA-3 status (all of them remained significant in the multivariate analysis). We identified three variables for the early identification of natalizumab optimal responders in a rapid and cost-effective approach.

Funder

Formación de Profesorado Universitario” -Ministerio de Educación, Cultura y Deporte

Spanish Biobanks Network

REEM: Red Española de Esclerosis Múltiple

Instituto de Salud Carlos III (ISCIII)-Fondo Europeo de Desarrollo Regional

Fundación Ramón Areces

Fundación LAIR

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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