Author:
Chen Hsiao-Lan,Chen Chia-Hung,Hsieh Wen-Che,Huang Yu-Han,Hsu Tzu-Ju,Tsai Fuu-Jen,Cheng Yung-Chi,Hsu Chao-Yu
Abstract
AbstractThis study aimed to investigate the association between obesity and herpes zoster (HZ) occurrence. This study used data covering 2 million people in Taiwan in 2000, which were obtained from the National Health Insurance Research Database. The cohort study observed aged 20–100 years with obesity from 2000 to 2017 (tracking to 2018). Obesity was indicated by the presence of two or more outpatient diagnoses or at least one admission record. And, obesity was categorized into non-morbid obesity and morbid obesity. Patients with HZ before the index date were excluded. The obesity cohort and control cohort were matched 1:1 according to age, sex, comorbidities, and index year. There were 18,855 patients in both the obesity and control cohorts. The obesity cohort [adjusted hazard ratio (aHR) 1.09] had a higher risk of HZ than the control cohort. Further analysis, the morbid obesity group (aHR 1.47), had a significantly higher risk of HZ than the non-morbid obesity group. Among the patients without any comorbidities, the patients with obesity had a significantly higher risk of developing HZ than the patients without obesity (aHR 1.18). Obese patients are at a higher risk of HZ development, especially in the patients with morbid obesity. Weight reduction is critical for preventing the onset of chronic diseases and decreasing the risk of HZ in patients with obesity.
Funder
Ditmanson Medical Foundation Chia-Yi Christian Hospital
Publisher
Springer Science and Business Media LLC
Reference34 articles.
1. Jaacks, L. M. et al. The obesity transition: Stages of the global epidemic. Lancet Diabetes Endocrinol. 7, 231–240 (2019).
2. Hales, C. M., Carroll, M. D., Fryar, C. D. & Ogden, C. L. Prevalence of obesity and severe obesity among adults: United States 2017–2018. NCHS Data Brief. 360, 1–8 (2020).
3. Hu, L. et al. Prevalence of overweight, obesity, abdominal obesity and obesity-related risk factors in southern China. PLoS ONE. 12, e0183934 (2017).
4. Wong, M. C. S. et al. Global, regional and time-trend prevalence of central obesity: A systematic review and meta-analysis of 13.2 million subjects. Eur. J. Epidemiol. 35, 673–683 (2020).
5. Keramat, S. A. et al. Obesity and the risk of developing chronic diseases in middle-aged and older adults: Findings from an Australian longitudinal population survey, 2009–2017. PLoS ONE. 16, e0260158 (2021).