Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions-Reference-Cited by-同舟云学术

Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions

Published:2017-12 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Qureshi O. S.,Rowley T. F.,Junker F.,Peters S. J.,Crilly S.^ORCID,Compson J.,Eddleston A.,Björkelund H.,Greenslade K.,Parkinson M.,Davies N. L.,Griffin R.,Pither T. L.^ORCID,Cain K.,Christodoulou L.,Staelens L.,Ward E.,Tibbitts J.,Kiessling A.,Smith B.,Brennan F. R.,Malmqvist M.,Fallah-Arani F.,Humphreys D. P.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-17255-8.pdf

Reference51 articles.

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2. Hogarth, P. M. & Pietersz, G. A. Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond. Nature reviews. Drug discovery 11, 311–331, https://doi.org/10.1038/nrd2909 (2012).

3. Bruhns, P. et al. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113, 3716–3725, https://doi.org/10.1182/blood-2008-09-179754 (2009).

4. Caaveiro, J. M., Kiyoshi, M. & Tsumoto, K. Structural analysis of Fc/FcgammaR complexes: a blueprint for antibody design. Immunological reviews 268, 201–221, https://doi.org/10.1111/imr.12365 (2015).

5. Li, X. & Kimberly, R. P. Targeting the Fc receptor in autoimmune disease. Expert opinion on therapeutic targets 18, 335–350, https://doi.org/10.1517/14728222.2014.877891 (2014).

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