Abstract
AbstractNo study has examined the associations between vitiligo and smoking. The purpose of this study was to investigate the incidence of vitiligo according to smoking status. We used clinical data from individuals aged over 20 years who received a health examination in the National Insurance Program between 2009 and 2012 (n = 23,503,807). We excluded individuals with pre-existing vitiligo who had ever been diagnosed with vitiligo before the index year (n = 35,710) or who were diagnosed with vitiligo within a year of the index year (n = 46,476). Newly diagnosed vitiligo was identified using claims data from baseline to date of diagnosis or December 31, 2016 (n = 22,811). The development of vitiligo was compared according to self-reported smoking status by a health examination survey. The hazard ratio of vitiligo in current smokers was 0.69 (95% confidence interval; 0.65–0.72) with a reference of never-smokers after adjustment for age, sex, regular exercise, drinking status, body mass index, diabetes mellitus, hypertension, dyslipidemia, history of stroke, and history of ischemic heart diseases. The decreased risk of vitiligo in current smokers persisted after subgroup analysis of sex and age groups. The results suggested there are suppressive effects of smoking on the development of vitiligo. Further studies are needed to evaluate the mechanism of smoking on the development of vitiligo.
Publisher
Springer Science and Business Media LLC
Reference70 articles.
1. Ezzedine, K., Eleftheriadou, V., Whitton, M. & van Geel, N. Vitiligo. Lancet 386, 74–84, https://doi.org/10.1016/S0140-6736(14)60763-7 (2015).
2. Behl, P. N. & Bhatia, R. K. 400 cases of vitiligo. A clinico-therapeutic analysis. Indian journal of dermatology 17, 51–56 (1972).
3. Canizares, O. Geographic dermatology: Mexico and Central America. The influence of geographic factors on skin diseases. Arch Dermatol 82, 870–893 (1960).
4. Furue, M. et al. Prevalence of dermatological disorders in Japan: a nationwide, cross-sectional, seasonal, multicenter, hospital-based study. The Journal of dermatology 38, 310–320, https://doi.org/10.1111/j.1346-8138.2011.01209.x (2011).
5. Howitz, J., Brodthagen, H., Schwartz, M. & Thomsen, K. Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark. Arch Dermatol 113, 47–52 (1977).
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