Author:
Mashiko Daisuke,Ikeda Zenki,Tokoro Mikiko,Hatano Yu,Yao Tatsuma,Kobayashi Tetsuya J.,Fukunaga Noritaka,Asada Yoshimasa,Yamagata Kazuo
Abstract
AbstractTo improve the performance of assisted reproductive technology, it is necessary to find an indicator that can identify and select embryos that will be born or be aborted. We searched for indicators of embryo selection by comparing born/abort mouse embryos. We found that asynchronous embryos during the 4–8-cell stage were predisposed to be aborted. In asynchronous mouse embryos, the nuclear translocation of YAP1 in some blastomeres and compaction were delayed, and the number of ICMs was reduced. Hence, it is possible that asynchronous embryos have abnormal differentiation. When the synchrony of human embryos was observed, it was confirmed that embryos that did not reach clinical pregnancy had asynchrony as in mice. This could make synchrony a universal indicator common to all animal species.
Funder
Japan Society for the Promotion of Science
Core Research for Evolutional Science and Technology
Publisher
Springer Science and Business Media LLC
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