Author:
Do Son Ngoc,Luong Chinh Quoc,Pham Dung Thi,Nguyen My Ha,Nguyen Nga Thi,Huynh Dai Quang,Hoang Quoc Trong Ai,Dao Co Xuan,Le Trung Minh,Bui Ha Nhat,Nguyen Hung Tan,Hoang Hai Bui,Le Thuy Thi Phuong,Nguyen Lien Thi Bao,Duong Phuoc Thien,Nguyen Tuan Dang,Vu Yen Hai,Pham Giang Thi Tra,Van Bui Tam,Pham Thao Thi Ngoc,Hoang Hanh Trong,Van Bui Cuong,Nguyen Nguyen Minh,Bui Giang Thi Huong,Vu Thang Dinh,Le Nhan Duc,Tran Trang Huyen,Nguyen Thang Quang,Le Vuong Hung,Van Nguyen Chi,McNally Bryan Francis,Phua Jason,Nguyen Anh Dat
Abstract
AbstractSepsis is the most common cause of in-hospital deaths, especially from low-income and lower-middle-income countries (LMICs). This study aimed to investigate the mortality rate and associated factors from sepsis in intensive care units (ICUs) in an LMIC. We did a multicenter cross-sectional study of septic patients presenting to 15 adult ICUs throughout Vietnam on the 4 days representing the different seasons of 2019. Of 252 patients, 40.1% died in hospital and 33.3% died in ICU. ICUs with accredited training programs (odds ratio, OR: 0.309; 95% confidence interval, CI 0.122–0.783) and completion of the 3-h sepsis bundle (OR: 0.294; 95% CI 0.083–1.048) were associated with decreased hospital mortality. ICUs with intensivist-to-patient ratio of 1:6 to 8 (OR: 4.533; 95% CI 1.621–12.677), mechanical ventilation (OR: 3.890; 95% CI 1.445–10.474) and renal replacement therapy (OR: 2.816; 95% CI 1.318–6.016) were associated with increased ICU mortality, in contrast to non-surgical source control (OR: 0.292; 95% CI 0.126–0.678) which was associated with decreased ICU mortality. Improvements are needed in the management of sepsis in Vietnam such as increasing resources in critical care settings, making accredited training programs more available, improving compliance with sepsis bundles of care, and treating underlying illness and shock optimally in septic patients.
Publisher
Springer Science and Business Media LLC
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