Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Author:

Masuda Hiroki,Mori Masahiro,Hirano Shigeki,Uzawa Akiyuki,Uchida Tomohiko,Muto Mayumi,Ohtani Ryohei,Aoki Reiji,Hirano Yoshiyuki,Iwatsubo Takeshi,Asada Takashi,Arai Hiroyuki,Sugishita Morihiro,Matsuda Hiroshi,Ito Kengo,Senda Michio,Ishii Kenji,Kuwano Ryozo,Ikeuchi Takeshi,Sato Noriko,Sato Hajime,Shimohama Shun,Saitoh Masaki,Yamauchi Rika,Hayashi Takashi,Kobayashi Seiju,Nakano Norihito,Kanazawa Junichiro,Ando Takeshi,Takanami Chiyoko,Hareyama Masato,Hatakenaka Masamitsu,Tsukamoto Eriko,Ochi Shinji,Shoji Mikio,Matsubara Etsuro,Kawarabayashi Takeshi,Wakasaya Yasuhito,Nakata Takashi,Nakahata Naoko,Ono Shuichi,Takai Yoshihiro,Takahashi Satoshi,Yonezawa Hisashi,Takahashi Junko,Kudoh Masako,Sasaki Makoto,Matsumura Yutaka,Hirata Yohsuke,Metoki Tsuyoshi,Hayakawa Susumu,Sato Yuichi,Takeda Masayuki,Sasaki Toshiaki,Sera Koichiro,Terasaki Kazunori,Saitoh Yoshihiro,Goto Shoko,Ueno Kuniko,Sakashita Hiromi,Watanabe Kuniko,Nagata Ken,Sato Yuichi,Maeda Tetsuya,Kondoh Yasushi,Yamazaki Takashi,Takano Daiki,Miyata Mio,Komatsu Hiromi,Watanabe Mayumi,Sinoda Tomomi,Muraoka Rena,Kikuchi Kayoko,Ito Hitomi,Sato Aki,Kinoshita Toshibumi,Toyoshima Hideyo,Sato Kaoru,Sugawara Shigeki,Ito Isao,Kumagai Fumiko,Furukawa Katsutoshi,Waragai Masaaki,Tomita Naoki,Okamura Nobuyuki,Ootsuki Mari,Sugawara Katsumi,Sugawara Satomi,Mugikura Shunji,Umetsu Atsushi,Murata Takanori,Nagasaka Tatsuo,Kudo Yukitsuka,Tashiro Manabu,Watanuki Shoichi,Nishizawa Masatoyo,Tokutake Takayoshi,Ishikawa Saeri,Kishida Emiko,Sato Nozomi,Hagiwara Mieko,Yamanaka Kumi,Watanabe Takeyuki,Takasugi Taeko,Inagawa Shoichi,Naito Kenichi,Awaji Masanori,Kanazawa Tsutomu,Okamoto Kouiti,Ikeda Masaki,Yamazaki Tsuneo,Tasiro Yuiti,Nagamine Syunn,Katsuyama Shiori,Kurose Sathiko,Fukushima Sayuri,Koya Etsuko,Amanuma Makoto,Oriuti Noboru,Ujita Kouiti,Kishi Kazuhiro,Tuda Kazuhisa,Mizukami Katsuyoshi,Arai Tetsuaki,Nakajima Etsuko,Miyamoto Katsumi,Saotome Kousaku,Kobayashi Tomoya,Itoya Saori,Ookubo Jun,Akatsu Toshiya,Anzai Yoshiko,Ikegaki Junya,Katou Yuuichi,Kimura Kaori,Kuchii Ryou,Saitou Hajime,Shinoda Kazuya,Someya Satoka,Taguchi Hiroko,Tashiro Kazuya,Tanaka Masaya,Nemoto Tatsuya,Wakabayashi Ryou,Watanabe Daisuke,Takano Harumasa,Suhara Tetsuya,Shinoto Hitoshi,Shimada Hitoshi,Higuchi Makoto,Mori Takaaki,Ito Hiroshi,Obata Takayuki,Fukushima Yoshiko,Suzuki Kazuko,Izumida Izumi,Tanimoto Katsuyuki,Shiraishi Takahiro,Shiba Junko,Yano Hiroaki,Satake Miki,Nakui Aimi,Ebihara Yae,Hasegawa Tomomi,Yoshiyama Yasumasa,Kato Mami,Ogata Yuki,Fujikawa Hiroyuki,Araki Nobuo,Nakazato Yoshihiko,Sasaki Takahiro,Shimadu Tomokazu,Yoshimaru Kimiko,Matsuda Hiroshi,Imabayashi Etsuko,Yasuda Asako,Yamamoto Etuko,Nakamata Natsumi,Miyauchi Noriko,Ozawa Keiko,Hashimoto Rieko,Unezawa Taishi,Ichikawa Takafumi,Hayashi Hiroki,Yamagishi Masakazu,Mihara Tunemichi,Hirano Masaya,Watanabe Shinichi,Fukuhara Junichiro,Matsudo Hajime,Saito Nobuyuki,Iwata Atsushi,Kowa Hisatomo,Hayashi Toshihiro,Ihara Ryoko,Miyagawa Toji,Yoshida Mizuho,Koide Yuri,Samura Eriko,Fujii Kurumi,Watanabe Kaori,Orihara Nagae,Momose Toshimitsu,Kunimatsu Akira,Mori Harushi,Takahashi Miwako,Arai Takuya,Kojima Yoshiki,Goto Masami,Sarashina Takeo,Uzuki Syuichi,Katou Seiji,Sekine Yoshiharu,Takauchi Yukihiro,Kagami Chiine,Kanemaru Kazutomi,Murayama Shigeo,Nishina Yasushi,Sakaibara Maria,Okazaki Yumiko,Okada Rieko,Obata Maki,Iwata Yuko,Minami Mizuho,Hanabusa Yasuko,Shingyouji Hanae,Tottori Kyoko,Tokumaru Aya,Ichinose Makoto,Kume Kazuya,Kahashi Syunsuke,Arima Kunimasa,Tukamoto Tadashi,Tanaka Shin,Nagahusa Yuko,Sakata Masuhiro,Okazaki Mitsutoshi,Saito Yuko,Yamada Maki,Kodama Tiine,Obata Maki,Takeuchi Tomoko,Ozawa Keiichiro,Iwata Yuko,Shingyouji Hanae,Hanabusa Yasuko,Kawaji Yoshiko,Tottori Kyouko,Sato Noriko,Nakata Yasuhiro,Sawada Satoshi,Mimatsu Makoto,Nakkamura Daisuke,Tamaru Takeshi,Horiuchi Shunichirou,Arai Heii,Ota Tsuneyoshi,Kodaka Aiko,Tagata Yuko,Nakada Tomoko,Iseki Eizo,Sato Kiyoshi,Fujishiro Hiroshige,Murayama Norio,Suzuki Masaru,Kimura Satoshi,Takahashi Masanobu,Hanyu Haruo,Sakurai Hirofumi,Umahara Takahiko,Kanetaka Hidekazu,Arashino Kaori,Murakami Mikako,Kito Ai,Miyagi Seiko,Doi Kaori,Sasaki Kazuyoshi,Yamazaki Mineo,Ishiwata Akiko,Arai Yasushi,Nogami Akane,Fukuda Sumiko,Tottori Kyouko,Minami Mizuho,Iwata Yuko,Kozaki Koichi,Yamada Yukiko,Kimura Sayaka,Machida Ayako,Kobayashi Kuninori,Mizusawa Hidehiro,Sanjo Nobuo,Watanabe Mutsufusa,Ohkubo Takuya,Utashiro Hiromi,Matsumoto Yukiko,Hagiya Kumiko,Miyama Yoshiko,Shinozaki Takako,Hiraki Haruko,Shibuya Hitoshi,Ohashi Isamu,Toriihara Akira,Ohtani Shinichi,Matsui Toshifumi,Hayasaka Yu,Toyama Tomomi,Sakurai Hideki,Sugiura Kumiko,Taguchi Hirofumi,Hatashita Shizuo,Imuta Akari,Matsudo Akiko,Wakebe Daichi,Hayakawa Hideki,Ono Mitsuhiro,Ohara Takayoshi,Washimi Yukihiko,Arahata Yutaka,Takeda Akinori,Konagaya Yoko,Yamaoka Akiko,Tsujimoto Masashi,Hattori Hideyuki,Sakurai Takashi,Hisayuki Miura,Endou Hidetoshi,Satake Syousuke,Hong Young Jae,Iwai Katsunari,Yoshiyama Kenji,Suenaga Masaki,Morita Sumiko,Kachi Teruhiko,Toba Kenji,Miura Rina,Kawai Takiko,Honda Ai,Kato Takashi,Fujiwara Ken,Katou Rikio,Koyama Mariko,Fukaya Naohiko,Tsuji Akira,Shimizu Hitomi,Fujisawa Hiroyuki,Nakazawa Tomoko,Koyama Satoshi,Sakata Takanori,Yamada Masahito,Yoshita Mitsuhiro,Samuraki Miharu,Ono Kenjiro,Shinohara Moeko,Soshi Yuki,Niwa Kozue,Doumoto Chiaki,Hata Mariko,Matsushita Miyuki,Tsukiyama Mai,Takeda Nozomi,Yonezawa Sachiko,Matsunari Ichiro,Matsui Osamu,Ueda Fumiaki,Ryu Yasuji,Sakamoto Masanobu,Ouchi Yasuomi,Chita Madoka,Fujita Yumiko,Majima Rika,Tsubota Hiromi,Shirasawa Umeo,Sugimori Masashi,Ariya Wataru,Hagiwara Yuuzou,Tanizaki Yasuo,Fukuyama Hidenao,Takahashi Ryosuke,Takechi Hajime,Namiki Chihiro,Uemura Kengo,Kihara Takeshi,Yamauchi Hiroshi,Tanaka-Urayama Shizuko,Maeda Emiko,Saito Natsu,Satomi Shiho,Kabata Konomi,Urayama Shin-Ichi,Okada Tomohisa,Ishizu Koichi,Kawase Shigeto,Fukumoto Satoshi,Nakagawa Masanori,Tokuda Takahiko,Kondo Masaki,Niwa Fumitoshi,Mizuno Toshiki,Oishi Yoko,Yamazaki Mariko,Yamaguchi Daisuke,Ito Kyoko,Asano Yoku,Hamaguchi Chizuru,Yamada Kei,Okuyama Chio,Akazawa Kentaro,Matsushima Shigenori,Matsuo Takamasa,Nakagawa Toshiaki,Nii Takeshi,Nishida Takuji,Kiuchi Kuniaki,Fukusumi Masami,Watanabe Hideyuki,Taoka Toshiaki,Nogi Akihiro,Takeda Masatoshi,Tanaka Toshihisa,Sato Naoyuki,Kazui Hiroaki,Yoshiyama Kenji,Kudo Takashi,Okochi Masayasu,Morihara Takashi,Tagami Shinji,Hayashi Noriyuki,Takaya Masahiko,Wada Tamiki,Yokokoji Mikiko,Sugiyama Hiromichi,Yamamoto Daisuke,Takeda Shuko,Nomura Keiko,Tomioka Mutsumi,Uchida Eiichi,Ikeda Yoshiyuki,Murakami Mineto,Miki Takami,Shimada Hiroyuki,Ataka Suzuka,Kanemoto Motokatsu,Takeuchi Jun,Takeda Akitoshi,Azuma Rie,Iwamoto Yuki,Tagawa Naomi,Masao Junko,Matsumoto Yuka,Kikukawa Yuko,Fujii Hisako,Matsumura Junko,Shiomi Susumu,Kawabe Joji,Shimonishi Yoshihiro,Miki Yukio,Higashida Mitsuji,Sahara Tomohiro,Yamanaga Takashi,Sakamoto Shinichi,Tsushima Hiroyuki,Maeda Kiyoshi,Yamamoto Yasuji,Kawamata Toshio,Sakai Kazuo,Oda Haruhiko,Sakurai Takashi,Akisaki Taichi,Adachi Mizuho,Kuranaga Masako,Takegawa Sachi,Tahara Yoshihiko,Terada Seishi,Ishihara Takeshi,Honda Hajime,Yokota Osamu,Kishimoto Yuki,Takeda Naoya,Imai Nao,Yabe Mayumi,Ida Kentaro,Anami Daigo,Inoue Seiji,Matsushita Toshi,Wada Reiko,Hiramatsu Shinsuke,Tonbara Hiromi,Yamamoto Reiko,Nakashima Kenji,Wada-Isoe Kenji,Yamasaki Saori,Yamashita Eijiro,Nakamura Yu,Ishikawa Ichiro,Danjo Sonoko,Shinohara Tomomi,Ueno Miyuki,Kashimoto Yuka,Nishiyama Yoshihiro,Yamamoto Yuka,Kimura Narihide,Ogawa Kazuo,Sasakawa Yasuhiro,Ishimori Takashi,Maeda Yukito,Yamada Tatsuo,Ouma Shinji,Fukuhara-Kaneumi Aika,Sakamoto Nami,Nagao Rie,Yoshimitsu Kengo,Kuwabara Yasuo,Nakamuta Ryuji,Tanaka Minoru,Ikeda Manabu,Hashimoto Mamoru,Kaneda Keiichirou,Yatabe Yuusuke,Honda Kazuki,Ichimi Naoko,Akatuka Fumi,Morinaga Mariko,Noda Miyako,Kitajima Mika,Hirai Toshinori,Shiraishi Shinya,Amano Naoji,Washizuka Shinsuke,Takahashi Toru,Inuzuka Shin,Hagiwara Tetsuya,Sugiyama Nobuhiro,Okada Yatsuka,Ogihara Tomomi,Yasaki Takehiko,Kitayama Minori,Owa Tomonori,Ryokawa Akiko,Takeuchi Rie,Goto Satoe,Yamauchi Keiko,Ito Mie,Kaneko Tomoki,Ueda Hitoshi,Ikeda Shuichi,Takao Masaki,Mihara Ban,Kubo Hirofumi,Takano Akiko,Yasui Gou,Akuzawa Masami,Yamaguchi Kaori,Odawara Toshinari,Shimamura Megumi,Sugiyama Mikiko,Watanabe Atsushi,Oota Naomi,Takebayashi Shigeo,Hayakawa Yoshigazu,Idegawa Mitsuhiro,Toya Noriko,Ishii Kazunari,Kuwabara Satoshi,

Abstract

AbstractWe aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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