Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in-Reference-Cited by-同舟云学术

Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in

Published:2019-03-05 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Rezza Amélie,Jacquet Christelle,Le Pillouer Amélie,Lafarguette Florian,Ruptier Charlotte,Billandon Marion,Isnard Petit Patricia,Trouttet Séverine,Thiam Kader,Fraichard Alexandre,Chérifi Yacine

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-40181-w.pdf

Reference28 articles.

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2. Komor, A. C., Badran, A. H. & Liu, D. R. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell 168, 20–36 (2017).

3. Garneau, J. E. et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468, 67–71 (2010).

4. Gasiunas, G., Barrangou, R., Horvath, P. & Siksnys, V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci USA 109, E2579–2586 (2012).

5. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).

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