Author:
Mirzaei Negin,Jahanian Sadatmahalleh Shahideh,Rouholamin Safoura,Nasiri Malihe
Abstract
AbstractTo study the effect of silymarin on the Interleukin-6 (IL-6) level, size of endometrioma lesion, pain, sexual function, and Quality of Life (QoL) in women diagnosed with endometriosis. This randomized, double-blind placebo-controlled clinical trial was performed on 70 women with endometriosis which was divided into two groups of intervention and control. The intervention was 140 mg silymarin (or matching placebo) administered twice daily for 12 weeks. The volume of endometrioma lesions, the level of IL-6 concentration in serum, pain, sexual function, and QoL were analyzed before and after the intervention. The means of endometrioma volume (P = 0.04), IL-6 (P = 0.002), and pain (P < 0.001) were reduced significantly in the silymarin group after intervention. However, the QoL and female sexual function did not improve substantially in the two groups (P > 0.05). Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms. The trial has been registered in the Iranian Registry of Clinical Trials (IRCT20150905023897N5) on 4th February 2020 (04/02/2020) (https://en.irct.ir/trial/42215) and the date of initial participant enrollment was 2nd March 2020 (02/03/2020).
Publisher
Springer Science and Business Media LLC
Reference72 articles.
1. Greene, A. D. et al. Endometriosis: Where are we and where are we going?. Reproduction 152(3), R63 (2016).
2. Ashrafi, M., Sadatmahalleh, S. J., Akhoond, M. R. & Talebi, M. Evaluation of risk factors associated with endometriosis in infertile women. Int. J. Fertil. Steril. 10(1), 11–21 (2016).
3. Giudice, L. C. Endometriosis. N. Engl. J. Med. 362(25), 2389–2398 (2010).
4. Culley, L. et al. The social and psychological impact of endometriosis on women’s lives: A critical narrative review. Hum. Reprod. Update 19(6), 625–639 (2013).
5. Soliman, A. M. et al. Health care utilization and costs associated with endometriosis among women with medicaid insurance. J. Manag. Care Spec. Pharm. 25(5), 566–572 (2019).
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