Author:
Kusumoto Tatsuya,Chubachi Shotaro,Namkoong Ho,Tanaka Hiromu,Lee Ho,Otake Shiro,Nakagawara Kensuke,Fukushima Takahiro,Morita Atsuho,Watase Mayuko,Asakura Takanori,Masaki Katsunori,Kamata Hirofumi,Ishii Makoto,Hasegawa Naoki,Harada Norihiro,Ueda Tetsuya,Ueda Soichiro,Ishiguro Takashi,Arimura Ken,Saito Fukuki,Yoshiyama Takashi,Nakano Yasushi,Mutoh Yoshikazu,Suzuki Yusuke,Edahiro Ryuya,Murakami Koji,Sato Yasunori,Okada Yukinori,Koike Ryuji,Kitagawa Yuko,Tokunaga Katsushi,Kimura Akinori,Imoto Seiya,Miyano Satoru,Ogawa Seishi,Kanai Takanori,Fukunaga Koichi
Abstract
AbstractThe severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.
Funder
Precursory Research for Embryonic Science and Technology
Japan Agency for Medical Research and Development
Core Research for Evolutional Science and Technology
Ministry of Health, Labour and Welfare
Publisher
Springer Science and Business Media LLC