Abstract
AbstractGiven the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for which available treatments are limited by low adherence. We designed a novel digital therapeutic that modifies patient-selected cinematic content in real-time into therapeutic visual input, while objectively monitoring adherence. The therapeutic design integrated a custom-designed headset that delivers precise visual input to each eye, computational algorithms that apply real-time therapeutic modifications to source content, a cloud-based content management system that enables treatment in the home, and a broad library of licensed content. In a proof-of-concept human study on the therapeutic, we found that amblyopic eye vision improved significantly after 12 weeks of treatment, with higher adherence than that of available treatments. These initial results support the utility of personalized therapy in amblyopia and may have broader relevance for improving treatment outcomes in additional indications.
Publisher
Springer Science and Business Media LLC
Reference29 articles.
1. DiMatteo, M. R., Haskard, K. B., Martin, L. R. & Williams, S. L. The challenge of patient adherence. Ther. Clin. Risk Manag. 1, 189–199 (2005).
2. Barash, C. I., Pursel, M. & Vogenberg, F. R. Personalized Medicine. P&T. 35, 560–562 (2010).
3. Schwaederle, M. et al. Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials. J. Clin. Oncol. 33, 3817–3825 (2015).
4. Pediatric Ophthalmology/Strabismus Preferred Practice Pattern Panel. Amblyopia Preferred Practice Pattern. Ophthalmol. 125, P105–P142 (2018).
5. Corliss, D. & Rutstein, R. P. Relationship between anisometropia, amblyopia, and binocularity. Optom. Vis. Sci. 76, 229–233 (1999).
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献