Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-20464-4.pdf
Reference27 articles.
1. Skipper, P. L. et al. Monocyclic aromatic amines as potential human carcinogens: old is new again. Carcinogenesis 31, 50–58 (2010).
2. Aizawa, Y. et al. Flutamide-induced hepatic dysfunction in relation to steady-state plasma concentrations of flutamide and its metabolites. Mol Cell Biochem. 252, 149–156 (2003).
3. Higuchi, R., Fukami, T., Nakajima, M. & Yokoi, T. Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, cyp2e1-, and cyp3a4-mediated metabolic activations. Drug Metab Dispos. 41, 1220–1230 (2013).
4. Guengerich, F. P. & Shimada, T. Oxidation of toxic and carcinogenic chemicals by human cytochrome p-450 enzymes. Chem Res Toxicol. 4, 391–407 (1991).
5. Schulz, M., Schmoldt, A., Donn, F. & Becker, H. The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment. Eur J Clin Pharmacol. 34, 633–636 (1988).
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