Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-00732-5.pdf
Reference32 articles.
1. Surprenant, A., Rassendren, F., Kawashima, E., North, R. A. & Buell, G. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor P2X7. Science 272, 735–738, doi: 10.1126/science.272.5262.735 (1996).
2. Kaczmarek-Hajek, K., Lorinczi, E., Hausmann, R. & Nicke, A. Molecular and functional properties of P2X receptors-recent progress and persisting challenges. Purinergic Signal 8, 375–417, doi: 10.1007/s11302-012-9314-7 (2012).
3. Browne, L. E., Compan, V., Bragg, L. & North, R. A. P2X7 receptor channels allow direct permeation of nanometer-sized dyes. J. Neurosci. 33, 3557–3566, doi: 10.1523/JNEUROSCI.2235-12.2013 (2013).
4. North, R. A. Molecular Physiology of P2X Receptors. Physiol Rev 82, 1013–1067, doi: 10.1152/physrev.00015.2002 (2002).
5. Miller, C. M. et al. The role of the P2X(7) receptor in infectious diseases. PLoS pathogens 7, e1002212, doi: 10.1371/journal.ppat.1002212 (2011).
Cited by 60 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. An Investigation on Linker Modifications of Cyanoguanidine‐Based P2X7 Receptor Antagonists;ChemMedChem;2024-07-12
2. Ionotropic purinergic receptor 7 (P2X7) channel structure and pharmacology provides insight regarding non-nucleotide agonism;Channels;2024-05-19
3. The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression;Biochemical and Biophysical Research Communications;2024-05
4. Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists;Current Medicinal Chemistry;2024-04
5. P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation;International Journal of Molecular Sciences;2024-02-21
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3