DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling

Author:

Badawy Shaymaa Mohamed Mohamed,Okada Taro,Kajimoto Taketoshi,Ijuin TakeshiORCID,Nakamura Shun-ichi

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference32 articles.

1. Gurevich, E. V., Tesmer, J. J., Mushegian, A. & Gurevich, V. V. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol. Ther. 133, 40–69 (2012).

2. Qanbar, R. & Bouvier, M. Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol. Ther. 97, 1–33 (2003).

3. O’Brien, P. J. & Zatz, M. Acylation of bovine rhodopsin by [3H]palmitic acid. J. Biol. Chem. 259, 5054–5057 (1984).

4. O’Dowd, B. F. et al. Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J. Biol. Chem. 264, 7564–7569 (1989).

5. Kennedy, M. E. & Limbird, L. E. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. J. Biol. Chem. 268, 8003–8011 (1993).

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