The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-40818-w.pdf
Reference38 articles.
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2. Crawford, S. et al. A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker. Mol Cancer Ther 7, 492–499, https://doi.org/10.1158/1535-7163.MCT-07-0307 (2008).
3. Elisei, R. et al. BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 93, 3943–3949, https://doi.org/10.1210/jc.2008-0607 (2008).
4. Fugazzola, L. et al. BRAF mutations in an Italian cohort of thyroid cancers. Clin Endocrinol (Oxf) 61, 239–243, https://doi.org/10.1111/j.1365-2265.2004.02089.x (2004).
5. Nucera, C., Lawler, J. & Parangi, S. BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res 71, 2417–2422, https://doi.org/10.1158/0008-5472.CAN-10-3844 (2011).
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